Pair Name	Curcumin, Arsenic trioxide
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Gene Regulation	Down-regulation	Expression	JAK2	hsa3717
	Down-regulation	Expression	STAT3	hsa6774
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	TP53	hsa7157
	Up-regulation	Expression	PSMD9	hsa5715
	Up-regulation	Expression	BAX	hsa581
In Vitro Model	KG-1a	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_1824
In Vivo Model	All mice were inoculated with KG1-a cells via the tail vein after pretreatment of 48 h, approximately 1.0×10⁷ cells per mouse.
Result	Our results suggested that curcumin and As2O3 combination therapy exerts more significant anti-leukemia effects in the treatment of AML than curcumin or As2O3 monotherapy by up-regulating p53 pathway and down-regulating the JAK2/STAT3 pathway.